发明名称 |
Targetable vector particles |
摘要 |
A vector particle (eg., a retroviral vector particle) containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell. The receptor of the target cell is other than the amphotropic cell receptor. The receptor binding region may be a receptor binding region of a human virus. A portion of the envelope gene may be deleted and the deleted portion is replaced with another receptor binding region or ligand. Such vector particles are targetable to a desired target cell or tissue, and may be administered directly to the desired target cell or tissue as part of a gene therapy procedure, or administered directly into the patient. |
申请公布号 |
AU5590194(A) |
申请公布日期 |
1994.06.08 |
申请号 |
AU19940055901 |
申请日期 |
1993.11.03 |
申请人 |
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF |
发明人 |
W. FRENCH ANDERSON;LEON F BALTRUCKI;JAMES M MASON |
分类号 |
C12N15/09;A61K35/76;A61K48/00;C07K14/15;C07K14/47;C12N5/10;C12N15/58;C12N15/867;C12N15/87 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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