发明名称 |
Method for the production of a modified 8-amino acid cyclosporin derivative |
摘要 |
A cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2-deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.
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申请公布号 |
US5318901(A) |
申请公布日期 |
1994.06.07 |
申请号 |
US19920911433 |
申请日期 |
1992.07.10 |
申请人 |
MERCK & CO., INC. |
发明人 |
PATCHETT, ARTHUR A.;WHITE, RAYMOND F.;GOEGELMAN, ROBERT T. |
分类号 |
A61K38/00;C07K7/64;C12P21/04;C12P21/08;(IPC1-7):C12P21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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