发明名称 |
1,5,7-TRISUBSTITUTED INDOLINE COMPOUNDS FOR THE TREATMENT OFDYSURIA |
摘要 |
Indoline compounds represented by the formula: <IMG> wherein R represents a saturated or unsaturated aliphatic acyl group which may have one or more halogen atoms, a hydroxy group, a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, a cycloalkyl group or an aryl group as substituents; a hydroxyalkyl group; an aliphatic acyloxyalkyl group; a lower alkyl group having a lower alkoxy group, a carboxy group, a lower alkoxycarbonyl group, an aryl ? substituted lower alkoxycarbonyl group, a carbamoyl group, a mono- or dialkyl substituted carbamoyl group or a cyano group as substituents; an aromatic acyl group which may have one or more halogen atoms as substituents; a furoyl group or a pyridylcarbonyl group; R1 represents a lower alkyl group which may have one or more halogen atoms or an aryl group as substituents; and pharmaceutically acceptable salts thereof, exhibit a selective suppressive action on urethral contractions, and thus are useful as therapeutic agents for the treatment of dysuria with less hypotension including postural hypotension.
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申请公布号 |
CA2110454(A1) |
申请公布日期 |
1994.06.03 |
申请号 |
CA19932110454 |
申请日期 |
1993.12.01 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
KITAZAWA, MAKIO;BAN, MASAAKI;OKAZAKI, KOSUKE;OZAWA, MOTOYASU;YAZAKI, TOSHIKAZU;YAMAGISHI, RYOICHI |
分类号 |
A61K31/40;A61K31/00;A61K31/403;A61K31/404;A61K31/44;A61K31/4427;A61K31/443;A61P9/02;A61P13/00;A61P13/02;A61P15/00;C07D209/08;C07D401/04;C07D401/06;C07D405/04;C07D405/06;(IPC1-7):C07D405/06;A61K31/402 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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