| 摘要 |
<p>PURPOSE:To obtain a new intermediate having a bone-absorption-suppressing action, bone-forming action and useful in treating bone diseases by using a compound known as Inhoffen-Lythgoe diol as a raw material. CONSTITUTION:A compound expressed by formula II (R1 is H or protecting group of hydroxyl group) and derived from a compound expressed by formula I and known as Inhoffen-Lythgoe diol is made to react with a carboxylic acid expressed by formula III (R2 is H or protecting group of hydroxyl group) to afford an ester body. Then the ester body is converted into a carboxylic acid expressed by formula IV by transfer reaction and a halogen such as iodine is added thereto and the carboxylic acid derivative is subjected to halolactonation reaction to provide the new compound expressed by formula V (X is iodine or halogen) and useful as a synthetic intermediate, etc., for vitamin D lactones having bone-absorption suppressing action or bone formation action and capable of expecting uses as a therapeutic agent for bone diseases.</p> |
