PROCESS FOR OBTAINING PROINSULIN POSSESSING CORRECTLY LINKEDCYSTINE BRIDGES

摘要

of the disclosure: Process for obtaining proinsulin possessing correctly liked cystine bridges A process is described for obtaining proinsulin possessing correctly linked cystine bridges from a corresponding proinsulin amino acid chain in the presence of mercaptan and chaotropic auxiliary agents and at a pH of 10 to 11, as well as its direct isolation from the reaction mixture using hydrophobic adsorber resins.