| 发明名称 |
HER4, a human receptor tyrosine kinase of the epidermal growth factor receptor family. |
| 摘要 |
The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180<erbB4,> are described. A HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4-derived and HER4-related biological compositions are provided. <IMAGE> |
| 申请公布号 |
EP0599274(A1) |
申请公布日期 |
1994.06.01 |
| 申请号 |
EP19930118837 |
申请日期 |
1993.11.23 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PLOWMAN, GREGORY D.;CULOUSCOU, JEAN-MICHEL;SHOYAB, MOHAMMED |
| 分类号 |
G01N33/53;A61K47/48;C07K14/475;C07K14/705;C07K14/71;C07K14/72;C07K16/00;C07K16/18;C07K16/28;C12N5/00;C12N5/10;C12N9/12;C12N15/00;C12N15/09;C12N15/12;C12P21/08;C12Q1/68;C12R1/91 |
主分类号 |
G01N33/53 |
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