发明名称 |
Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
摘要 |
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
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申请公布号 |
US5317013(A) |
申请公布日期 |
1994.05.31 |
申请号 |
US19920945215 |
申请日期 |
1992.09.15 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
GOODMAN, MICHAEL G.;WEIGLE, WILLIAM O. |
分类号 |
C07H19/16;(IPC1-7):A61K31/70;A61K45/05;C07K13/00 |
主分类号 |
C07H19/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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