| 摘要 |
The invention relates to tricyclic heterocycles of the formula I <IMAGE> wherein X is oxy, thio, sulphinyl, sulphonyl, amino, (1-4C)alkylamino or methylene; Y is carbonyl or methylene; each R1 includes hydrogen, halogeno and various other substituents; each of m and n is 1 or 2; A1, alkylene, alkenylene or alkynylene; Het is a 5 or 6 membered heteroaryl group optionally bearing particular substituents; and G is carboxy, 1H-tetrazol-5-yl or a group of the formula: -CONH-SO2R2 wherein R2 is (1-4C)alkyl, benzyl or phenyl; and pharmaceutically-acceptable salts thereof, which possess anti-hyperalgesic properties. The invention also relates to processes for the manufacture of said tricyclic heterocycles; and to novel pharmaceutical compositions containing them.
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