| 摘要 |
"Carboxamide Derivatives" This invention provides a series of novel heterocyclic carboxamides of Formula I <IMG> I in which the group -Y-Z< is selected from -C(Ra)=C<, -N=C<, and -CH(Ra)-CH< and the other radicals have the meanings defined in the following specification. The compounds of Formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the Formula I compounds; pharmaceutical compositions containing the Formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the Formula I compounds, as well as intermediates for use in such manufacture.
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