发明名称 |
Short-term anti-CD3 stimulation of lymphocytes to increase their in vivo acitivity |
摘要 |
The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
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申请公布号 |
US5316763(A) |
申请公布日期 |
1994.05.31 |
申请号 |
US19920910835 |
申请日期 |
1992.07.10 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
OCHOA, AUGUSTO C.;LOEFFLER, CYNTHIA;URBA, WALTER;LONGO, DAN L. |
分类号 |
A61K38/00;A61K35/12;A61K35/14;A61K38/20;A61K39/395;A61P35/00;C12N5/0783;(IPC1-7):A61K35/14;A61K45/05;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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