发明名称 |
C-GLYCOSIDE ANALOGUES OF N-(4-HYDROXYPHENYL)RETINAMIDE-O-GLUCURONIDE |
摘要 |
The present invention provides breast cancer chemopreventive arylamide analogues of retinoic acid, more particularly C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide that resist both beta -glucuronidase mediated enzymatic hydrolysis as well as acid catalyzed hydrolysis. Specifically, the drugs include 4-(retinamido)phenyl-C-glucuronide; 4-(retinamido)phenyl-C-glucoside; 4-(retinamido)benzyl-C-xyloside; 4-(retinamido)benzyl-C-glucoside; 4-(retinamido)benzyl-C-glucuronide; and 4-(retinamido)phenyl-C-xyloside. |
申请公布号 |
WO9411030(A1) |
申请公布日期 |
1994.05.26 |
申请号 |
WO1993US10998 |
申请日期 |
1993.11.12 |
申请人 |
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
CURLEY, ROBERT, W., JR.;PANIGOT, MICHAEL, J. |
分类号 |
A61K31/70;C07D309/10;C07H13/04;C07H13/06;(IPC1-7):A61K47/26;A61K31/595;A61K31/165;C07H7/04 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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