发明名称 |
M-EDTA PHARMACEUTICAL PREPARATIONS AND USES THEREOF |
摘要 |
Disclosed are pharmaceutical compositions of a mixture of minocycline and EDTA (M-EDTA) and methods of using the compositions in maintaining the patency of a catheter port. Methods for inhibiting the formation of polysaccharide-rich glycocalyx (such as the glycocalyx of staphylococcal organisms) are also provided using an M-EDTA solution. A solution including minocycline, EDTA or both, may also be used to pretreat a medical device to prevent adherence of infectious organisms, such as S. epidermidis and S. aureus. The compositions destroy and prevent the formation of polysaccharide-rich glycocalyx. Methods for treating infections of S. epidermidis and S. aureus where glycocalyx formation are provided with an M-EDTA solution. The minocycline and EDTA solutions are included together within a pharmacologically acceptable carrier solution, such as saline. |
申请公布号 |
WO9410838(A1) |
申请公布日期 |
1994.05.26 |
申请号 |
WO1993US10893 |
申请日期 |
1993.11.12 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
RAAD, ISSAM;SHERERTZ, ROBERT, J. |
分类号 |
A61M25/00;A01N37/44;A01N47/12;A61L29/00;A61L29/08;A61L29/16;A61L31/00;(IPC1-7):A01N25/02;A01N25/08;A61F2/04;A61M25/01 |
主分类号 |
A61M25/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|