PEPTIDE INHIBITORS OF FIBRONECTIN AND RELATED COLLAGEN-BINDING PROTEINS

摘要

2148383 9411395 PCTABS00032 Peptides derived from the second type 1 repeat of human endothelial cell thrombospondin which bind to the gelatin-binding domain of fibronectin have been isolated and synthetically produced. The peptides can be used to bind to fibronectin or other related collagen-binding proteins to inhibit fibronectin-dependant cell adhesion to collagen matrices and to inhibit interactions with collagen of other proteins that share homologies with the gelatin-binding domain of fibronectin.