ADENOVIRUS-MEDIATED GENE TRANSFER TO CARDIAC AND VASCULAR SMOOTH MUSCLE

摘要

2149771 9411506 PCTABS00032 The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.