1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS

摘要

Compounds of formula (I) in which n = 0, 1 or 2; R1, R2, R6 and R7 independently represent H or alkyl (optionally substituted by one or more halo); R3 and R4 independently represent H or alkyl or together represent a group of formula = NR12 where R12 represents H, hydroxy, alkyl, phenyl or alkoxy; each alkyl, phenyl and alkoxy being optionally substituted with one or more halo; R5 represents: (a) H, (b) alkyl, (c) a group of formula -COR13 in which R13 is H, alkyl or phenyl, when R3 and R4 represent H or alkyl (optionally substituted with one or more halo), or (d) a group of formula -S(O)pR14 in which p = 1 or 2 and R14 is alkyl or phenyl, when R3 and R4 represent H or alkyl (optionally substituted with one or more halo); each alkyl and phenyl optionally substituted with one or more halo; and R8 to R11 independently represent H, halo, cyano, nitro, alkyl alkoxy, alkanoyl, carboxy, alkanoyloxy, carbamoyl (optionally substituted with alkyl) or sulphamoyl (optionally substituted with alkyl of 1 to 4 carbon atoms); each alkyl, alkoxy, alkanoyl or alkanoyloxy optionally substituted with one or more halo; have utility in the treatment of seizures and/or neurological disorders such as epilepsy and/or as neuroprotective agents to protect against conditions such as stroke.