| 摘要 |
<p>2-(Pyrid-2'-yl)-2-thiazoline-4-carboxylic acid derivatives of formula (I) in which R1 represents hydrogen, halogen, hydroxy, C1-C4 alkoxy or C1-C4 alkyl; R2 represents hydroxy or resterified hydroxy; and R3 represents etherified hydroxy or a group of the partial formula -N(R4, R5) in which R4 and R5 independently from each other represent hydrogen or C1-C4 alkyl or in which R4 represents hydroxy or esterified hydroxy and R5 represents hydrogen, C1-C4 alkyl or a group -X-R6 in which X is C2-C12 alkylen or oxaalkylen having 4-12 chain members and R6 represents C1-C2 alkyl or a hydroxylamino group -N(OH)-R7 in which R7 represents C1-C4 alkanoyl; and salts thereof form chelate-type metal complexes with trivalent metal ions, especially iron (III), and can be used, for example, for the treatment of pathological conditions in warm-blooded animals that are associated with an excess of trivalent metal ions in the body. Valuable starting material embraces alkali and alkaline earth salts of 2-(3'hydroxypyrid-2'-yl)-2-thiazoline-4(S)-carboxylic acid.</p> |
