| 发明名称 |
MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TO TUMOR VASCULAR ENDOTHELIUM AND USES THEREOF |
| 摘要 |
2149120 9411023 PCTABS00032 The invention involves monoclonal antibodies which specifically bind to a cell surface antigen characteristic of tumor vascular endothelium. The antigen, referred to as endosialin, is a glycoproteine and has a molecular weight of about 165 kDa as determined by SDS-PAGE. The protein portion of the molecule has a molecular weight of about 95 kDa. Also disclosed are various uses of the monoclonal antibody and the antigen.
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| 申请公布号 |
CA2149120(A1) |
申请公布日期 |
1994.05.26 |
| 申请号 |
CA19932149120 |
申请日期 |
1993.11.09 |
| 申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH;MEMORIAL SLOAN-KETTERING CANCER CENTER |
发明人 |
GARIN-CHESA, PILAR;RETTIG, WOLFGANG J.;OLD, LLOYD J. |
| 分类号 |
G01N33/53;A61K9/127;A61K38/00;A61K39/00;A61K39/395;A61K45/00;A61P35/00;C07H21/04;C07K14/47;C07K16/30;C12N5/10;C12N15/02;C12P21/08;C12R1/91;(IPC1-7):C12N5/12;A61K47/48;G01N33/574;G01N33/577;C07K14/705 |
主分类号 |
G01N33/53 |
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