PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES, NOVEL TAXANES SO OBTAINED AND ANTITUMOUR AND ANTILEUKAEMIA COMPOSITIONS CONTAINING SAME

摘要

Process for the electrochemical preparation of taxane derivatives of general formula (I), based on a taxane derivative of general formula (III). The invention also concerns pharmaceutical compositions with outstanding antitumour and antileukaemia properties which contain a novel product of general formula (I) wherein R3 is a radical of general formula (II). In general formulae (I) and (III), R is a hydrogen atom or an acetyl or alkoxyacetyl radical, one of the symbols R1 or R2 is a hydrogen atom and the other is a hydroxy radical, R3 is a hydrogen atom or a radical of general formula (II) wherein Ar is an aryl radical and R4 is a benzoyl radical or a R5-O-CO- radical in which R5 is an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical.