CDNAS ENCODING HUMAN NMDA-22A RECEPTOR SUBUNIT AND ISOFORMS OF THE HUMAN NMDA-R1 RECEPTOR SUBUNIT, TRANSFECTED CELL LINE EXPRESSING THEM

摘要

2148599 9411501 PCTABS00032 The present invention relates to a stably co-transfected eukaryotic cell line capable of expressing an N-methyl-D-aspartate (NMDA) receptor, particularly a human NMDA receptor, which receptor comprises at least one R1 subunit isoform, or at least one R1 subunit isoform and one or two R2 subunits; to the cloning of novel cDNA sequences encoding the human NMDA R2A subunit and various isoforms of the human NMDA R1 subunit; and to the use of the cell line in designing and developing NMDA receptor subtype-selective medicaments.