5-Thia-1,4-diazabicyclo¬4.2.0 octane-3,8-dioxo analogs of beta-lactam, processesfor the preparation thereof and the use thereof

摘要

Disclosed are novel 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo beta -lactam analogs of the general formula I <CHEM> wherein R<1> is hydrogen or halo; R<2> is hydrogen, halo, amino, PhCH2CONH, PhOCH2CONH, phthalimido, o-MeNHCO-C6H4-CONH, isoxazolylcarboxamido; R<3> is hydrogen, alkyl, benzyl, heterocycle, e.g. isoxazole, pyrazole etc., and n may be 1 or 2. They may be used as intermediates in preparing novel beta -lactam analogs or as active substances in formulations for antimicrobial therapy.