| 摘要 |
PURPOSE:To provide a medicine containing WF11243 substance (salt) exhibiting specified physical properties as the active component, excellent in safety and phylaxis effect and useful for preventing and improving carinii pneumon: a, etc. CONSTITUTION:The medicine contains WF11243 substance represented by the formula or its salt as the active component. In addition, hydrochloride of WF11243 substance exhibits, e.g. following physical properties; color and state of substance: white powder; melting point: 182 to 187 deg.C; specific rotatory power: [alpha]<23>D is +29 deg. (C=1.5, methanol); molecular formula: C71H115N14O23.HCl; elemental analysis: calculated value (wt.%) (as C71H115N14O23.HCl.8H2O) C: 49.74, H: 7.82 and N: 11-44, experimental value (wt.%): C: 49.65, H: 7.72 and N: 11.40; solvent solubility: readily soluble in methanol or water, sparlingly soluble in acetone and insoluble in n-hexane; color reaction: Iodine vapor reaction, cerium sulfate reaction and ninhydrin reaction are positive and Molisch reaction and Ehrlich reaction are negative; The dosage is preferably 0.5 to 100mg/kg per day on active component base. |
