发明名称 |
Method for imaging informational biological molecules on a semiconductor substrate |
摘要 |
Imaging biological molecules such as DNA at rates several times faster than conventional imaging techniques is carried out using a patterned silicon wafer having nano-machined grooves which hold individual molecular strands and periodically spaced unique bar codes permitting repeatably locating all images. The strands are coaxed into the grooves preferably using gravity and pulsed electric fields which induce electric charge attraction to the molecular strands in the bottom surfaces of the grooves. Differential imaging removes substrate artifacts.
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申请公布号 |
US5314829(A) |
申请公布日期 |
1994.05.24 |
申请号 |
US19920992601 |
申请日期 |
1992.12.18 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
COLES, L. STEPHEN |
分类号 |
B01L3/00;C07B61/00;C07K1/04;C40B70/00;G01N33/48;G01N35/00;G01Q30/20;G01Q70/14;(IPC1-7):G01N21/03 |
主分类号 |
B01L3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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