发明名称 |
METHODS AND MATERIALS FOR EXPRESSION OF HUMAN PLASMINOGEN VARIANT. |
摘要 |
<p>A cleavage-resistant plasminogen molecule is provided that is conveniently produced in recombinant cells by expression of a nucleic acid sequence encoding the plasminogen molecule. Preferably the plasminogen is a sequence variant with a modification in its two-chain cleavage site. The plasminogen molecule may be purified, acylated, complexed with acylated or non-acylated fibrinolytic enzymes, and formulated into pharmaceutical compositions for use in thrombolytic therapy.</p> |
申请公布号 |
EP0502872(B1) |
申请公布日期 |
1994.05.18 |
申请号 |
EP19900916888 |
申请日期 |
1990.10.31 |
申请人 |
GENENTECH, INC. |
发明人 |
CASTELLINO, FRANCIS, J.;HIGGINS, DEBORAH, L. |
分类号 |
A61K38/48;A61K38/00;A61K38/46;A61K38/54;A61P7/02;C07K14/315;C12N1/21;C12N5/10;C12N9/68;C12N15/09;C12N15/57;(IPC1-7):C12N15/57;A61K37/54 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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