| 摘要 |
Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: <CHEM> wherein R<1> is cyclopropyl which may have 1 to 3 substituents of alkyl and halogen; phenyl which may be substituted by 1 to 3 substituents of alkoxy, halogen and OH; alkyl which may be substituted by halogen, alkanoyloxy or OH; alkenyl; or thienyl, R<2> is 5- to 9-membered saturated or unsaturated heterocyclic ring which may be sustituted, R<3> is H, alkyl or halogen, R<4> is alkyl or halogen, R is H or alkyl, R<1> and R<3> may be taken together to form <CHEM> wherein R<3><1> is H or alkyl, and X is halogen, provided that R<3> and R<4> are not simultaneously halogen, and that when R<3> is H, R<4> is alkyl, and salts thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition containing said compound as an active ingredient. |
