| 摘要 |
The invention relates to an immunological complex of two primary antibodies, which have been conjugated to form a cyclic tetramer with two linker antibodies directed against the Fc-fragments of the primary antibodies. Preferably, the complex is bifunctional, that is to say, that it contains two different primary antibodies, one of which is preferably directed to a detectable substance, such as an enzyme, e.g. peroxidase, and the other is directed to any desired antigen. A tetrameric complex of this kind may be used as a labelled antibody in immunoassays. Further, the invention relates to processes for preparing the complexes and for using the complexes in immunological reactions. Finally, the invention relates to drugs containing a complex according to the invention, as the complexes may be used to direct certain active principles to target cells.
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