发明名称 |
LIPOSOMAL PREPARATION AND ANTIBIOTIC |
摘要 |
This invention relates to liposomes comprising at least one nonguanidino nonphosphate aminoglycoside present in a drug to lipid ratio (eq. wt.) of at least about 3:50 (w/w), to liposomes comprising at least one guanidino nonphosphate aminoglycoside present in a drug (eq. wt.) to lipid ratio of at least about 9:25 (w/w), and to a method of preparing aminoglycoside-containing SPLV liposomes having a drug to lipid ratio (eq. wt.) of at least about 3:50 (w/w), the method comprising: a) dissolving at least one amphipathic lipid in organic solvent; b) adding to the solution formed by step (a) an aqueous phase and an aminoglycoside, thus forming a biphasic mixture; c) emulsifying the aqueous phase within the organic solvent while evaporating the solvent; and d) stabilizing the material resulting from (c) by maintaining the material in a hydrated state for at least about 8 hours.
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申请公布号 |
CA1329548(C) |
申请公布日期 |
1994.05.17 |
申请号 |
CA19920616438 |
申请日期 |
1992.07.13 |
申请人 |
LIPOSOME COMPANY, INC. (THE) |
发明人 |
BALLY, MARCEL B.;BOLCSAK, LOIS E.;CULLIS, PIETER R.;JANOFF, ANDREW S.;MAYER, LAWRENCE D.;LINK, ROBERT P.;JEDRUSIAK, JO ANN |
分类号 |
A61K9/127;(IPC1-7):A61K9/127;A61K31/71 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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