发明名称 |
Ligands for improving metal chelate formation kinetics |
摘要 |
Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include a tertiary amine strategically located to facilitate rapid formation of an amine-amide-thiolate intermediate complex, followed by transfer of the metal to a thermodynamically stable amide-thiolate complex. The amide-thiolate ligands of the present invention may be used for post formed labeling of biological substances for use in the fields of diagnosis and therapy.
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申请公布号 |
US5310536(A) |
申请公布日期 |
1994.05.10 |
申请号 |
US19920832149 |
申请日期 |
1992.02.06 |
申请人 |
MALLINCKRODT MEDICAL, INC. |
发明人 |
SRINIVASAN, ANANTHACHARI |
分类号 |
A61K51/04;A61K51/08;C07D213/40;C07D213/64;C07D213/68;C07F13/00;(IPC1-7):A61K49/02;A61K43/00 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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