| 摘要 |
Certain 3,4-disubstituted anilines and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: <IMAGE> FORMULA I wherein Y is <IMAGE> <IMAGE> NHSO2 or SO2NH where R4 is H; Z is -O-, -NH-, -NR-, -S-, or other heteroatoms capable of hydrogen bonding with R4 to give a preferred conformation; R is alkyl; R1 is -NH2 or -NHCH3; R2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and R3 is a lipophilic moiety.
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