Fowlpox virus non-essential regions

摘要

PCT No. PCT/GB89/00698 Sec. 371 Date Nov. 28, 1990 Sec. 102(e) Date Nov. 28, 1990 PCT Filed Jun. 22, 1989 PCT Pub. No. WO89/12684 PCT Pub. Date Dec. 28, 1989.The invention relates to DNA from fowlpox virus (FPV) providing a non-essential region for the insertion of foreign genes thereinto and thence the construction of a vector for homologous recombination with a wild type FPV, whereby the resulting recombinant FPV can be used for vaccination of animals, especially chickens. In this invention, the non-essential region consists substantially of a length of DNA from the long unique sequence of the terminal inverted repeat (TIR) of FPV or from the region at FPV which corresponds approximately to the HindIII D fragment genes D8 and D9 in vaccinia virus.