| 摘要 |
The present invention is directed to a transdermal delivery device (10) for the controlled release of a drug or other therapeutic agent to skin or mucosa and adapted to delay the onset of therapeutic agent delivery at a therapeutically effective rate for a predetermined time after placement of the device onto the skin or mucosa. The device comprises a nonaqueous reservoir (104) which contains a therapeutic agent in complexation with an ion-exchange resin and also contains an activating agent, the reservoir having a surface through which the therapeutic agent is released to the skin or mucosa; and a rate-controlling membrane (106) disposed between the skin or mucosa and the releasing surface of the reservoir (104) for controlling the rate at which water is absorbed into the reservoir, the rate-controlling membrane (106) being substantially free of therapeutic agent prior to placement of the device onto the skin or mucosa. The present invention has the additional advantage of providing the therapeutic agent in a stable form prior to placement on the skin or mucosa as well as in a form suitable for absorption after such placement. |
