发明名称 Pure enantiomers of phosphoric-acid esters as phospholipase-a2 inhibitors
摘要 The invention concerns compounds of the general formula (I), in which R<1> is a C10-C22 alkyl group, R<2> is an O-CO-R<4>, NH-CO-R<4>, -OH, -OCH3, -OC2H5, -OC3H7, -NH2, -NHCH3, -N(CH3)2 or -N<+>(CH3)3Cl<-> group, R<4> is a C1-C20 alkyl group and R<3> is one of the following groups: -C2H4-N<+>(CH3)3, -C2H4-N<+>H(CH3)2, -C2H4-N<+>H2CH3, -C2H4-N<+>H3, pentahydroxycyclohexanyl derivatives, in particular myo-inositol derivatives, 1,2- or 2,3-(R or S)-dihydroxypropanyl, seryl (D or L), N-methylseryl (D or L), N,N-dimethylseryl, (D or L), N,N,N-trimethylseryl (D or L), H, methyl, ethyl, hydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, R<2> and (II) being interchangeable with each other, plus enantiomers thereof.
申请公布号 AU5150093(A) 申请公布日期 1994.05.09
申请号 AU19930051500 申请日期 1993.10.08
申请人 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. 发明人 HANSJORG EIBL;ULRICH MASSING;CLEMENS UNGER
分类号 A61K31/66;A61P7/02;A61P29/00;A61P43/00;C07F9/09;C07F9/117 主分类号 A61K31/66
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