| 摘要 |
PURPOSE:To produce octacalcium phosphate improved in its purity by mixing calcium hydrogen phosphate with a non-calcium phosphate salt in a specific Ca/P atomic ratio in water and subsequently subjecting the formed aqueous suspension to reaction at a prescribed temperature. CONSTITUTION:A non-calcium phosphate salt such as CaCO3 having a solubility of >=0.0015g/100g in water is dissolved in water, and the produced aqueous solution is mixed with calcium hydrogen phosphate such as CaHPO4 or CaHPO4.2H2O having high surface slipperiness and proper solubility in an atomic Ca/P ratio of 1.30-1.60 to prepare the aqueous suspension having a solid concentration of 1-4wt.%. The aqueous suspension is subjected to a reaction at 35-68 deg.C for 5-50hr with stirring, and the reaction product is filtered off, dried under vacuum, and further dried by heating at <=65 deg.C to provide the highly pure octacalcium phosphate [Ca8H2(PO4)6.5H2O] in good yield. |
