摘要 |
<p>The invention relates to carbazolone derivatives of the formula <CHEM> wherein A stands for a group of formula -CH2-R (V), wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group; B represents a group of formula <CHEM> wherein R1 means hydrogen or a methyl or ethyl group; or A and B together form a group of formula <CHEM> wherein R2 means a methyl or ethyl group; or A and B together form a group of formula <CHEM> The above compounds are useful intermediates in the synthesis of ondansetron of formula <CHEM> chemically 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-c arbazol-4-one. The invention further relates to a novel process for the preparation of compounds of the formula (I), wherein A and B are the same as in formula (I).</p> |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
BOD, PETER, DR.;HARSANYI, KALMAN, DR.;TRISCHLER, FERENC, DR.;FEKECS, EVA;CSEHI, ATTILA;HEGEDUS, BELA, DR.;MERSICH NEE DONAT, EVA;SZABO NEE KOML SI, GYOERGYI;HORVATH NEE SZIKI, ERIKA |