2-AMINO-TETRAHYDRO-ISOQUINOLINE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

A b s t r a c t The present invention relates to tetrahydro-isoquinoline derivatives of the general Formula (I) <IMG> I. wherein R stands for hydrogen or chlorine R1 and R2 stand for hydrogen, methoxy or ethoxy R3 and R4 stand for hydrogen or methyl and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the general Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the general Formula(II) <IMG> II. wherein R1, R2, R3 and R4 are as given above - with a carboxylic acid derivative of the general Formula(III) <IMG> III. wherein X stands for chlorine, -OH, -OCH2CN, -OCH3, -OC2H5, -OCOOCH3 or -OCOOC2H5 R5 and R6 stand for hydrogen or together form CHN(CH3)2 and in case of the general Formula (Ia) <IMG> wherein R. R1, R2, R3 and R4 are as given above splitting off the protective group in alkaline medium. The compound of Formula (I) have diuretic or saluretic utility.