| 摘要 |
<p>Novel taxane derivatives of general formula (I), their preparation by electrochemical reduction of a taxane derivative of general formula (III) and pharmaceutical compositions containing a product of general formula (I) in which R3 is a radical of general formula (II) having outstanding antitumor and antileukemia properties. In general formula (I), one of the symbols R1 or R2 is a hydrogen atom while the other is a hydroxy radical, R3 is a hydrogen atom or a radical of general formula (II) wherein Ar is an aryl radical and R4 is a benzoyl radical or an R5-O-CO- radical in which R5 is an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical and R6 is an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl optionally substituted aryl or heterocyclyl radical.</p> |
