| 摘要 |
<p>The substitution of at least one of the amino acids in positions 2 to 5 of the bradykinin peptide with a fatty acid amine converts bradykinin agonists into a bradykinin antagonist. The invention further includes the intermediate compounds and additional modifications at other positions within the modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected as by insect bites.</p> |
