发明名称 |
METHOD OF PREPARING AMINOALKYLHYDANTOINS AND AMINOALKYL- alpha -AMINOACIDS |
摘要 |
<p>In order to prepare aminoalkylhydantoins, the amino function must be protected before the formation of the hydantoin ring. Since the protective group is difficult to remove again, however, in particular for subsequent enzymatic reactions in which the corresponding aminoacids are liberated, a simple method of preparing aminoalkyl compounds was sought. The invention calls for an acid-labile amino-protecting group to be used in the preparation of compounds of general formula (I) or (II) in which X is alkylene and Y is hydrogen or alkyl. This protective group can even be split off during the acid-catalysed hydantoin ring closure since, during this step, no competing reactions of the freed amino function take place. The method disclosed is suitable for use in the preparation of optically opposite D- and L-forms of natural and synthetic aminoacids.</p> |
申请公布号 |
WO9408974(A1) |
申请公布日期 |
1994.04.28 |
申请号 |
WO1993EP02753 |
申请日期 |
1993.10.08 |
申请人 |
DEGUSSA AKTIENGESELLSCHAFT |
发明人 |
KOTTENHAHN, MATTHIAS;DRAUZ, KARLHEINZ;BOMMARIUS, ANDREAS |
分类号 |
C07C227/24;C07C227/30;C07C229/26;C07D233/72;C07D233/76;(IPC1-7):C07D233/76;C12P13/10;C12P13/08 |
主分类号 |
C07C227/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|