发明名称 |
FIBRINOGEN RECEPTOR ANTAGONISTS |
摘要 |
Novel fibrinogen receptor antagonists of the formula: X-Y-Z-Aryl-A-B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsubstituted or substituted with R5 and wherein S may be substituted with 0, 1 or 2 oxygen atoms; and X comprises various Nitrogen substituents including aromatic or nonaromatic systems; Y comprises, for example, alkyl or alkylaminocarbonylalkyl groups and Z and A are substituents which when present are independently chosen from alkyl or alkyloxyalkyl or other groups as defined herein; B is (a) or (b). The claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating or preventing thrombus formation.
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申请公布号 |
CA2144762(A1) |
申请公布日期 |
1994.04.28 |
申请号 |
CA19932144762 |
申请日期 |
1993.10.12 |
申请人 |
MERCK & CO., INC. |
发明人 |
HARTMAN, GEORGE D.;PRUGH, JOHN D.;EGBERTSON, MELISSA S.;DUGGAN, MARK E.;HOFFMAN, WILLIAM |
分类号 |
A61K31/38;A61K31/381;A61K31/4427;A61K31/4433;A61K31/445;A61K31/454;A61P7/02;C07C311/06;C07C311/19;C07D233/64;C07D333/38;C07D401/12;C07D409/06;C07D409/12;C07D413/12;(IPC1-7):C07D409/12 |
主分类号 |
A61K31/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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