| 发明名称 |
METHOD OF CLEAVING SPECIFIC STRANDS OF RNA |
| 摘要 |
A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2', 5'-dependent RNase. |
| 申请公布号 |
WO9409129(A2) |
申请公布日期 |
1994.04.28 |
| 申请号 |
WO1993US10103 |
申请日期 |
1993.10.20 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS;THE CLEVELAND CLINIC RESEARCH INSTITUTE |
发明人 |
TORRENCE, PAUL;SILVERMAN, ROBERT;MAITRA, RATAN;LESIAK, KRYSTYNA |
| 分类号 |
C12N15/09;C07H21/00;C07H21/02;C12N9/16;C12N15/113;(IPC1-7):C12N15/11;A61K31/70;C07H21/04 |
主分类号 |
C12N15/09 |
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