| 摘要 |
PCT No. PCT/US93/09137 Sec. 371 Date Feb. 23, 1995 Sec. 102(e) Date Feb. 23, 1995 PCT Filed Sep. 27, 1993 PCT Pub. No. WO94/07481 PCT Pub. Date Apr. 14, 1994Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as arthritis, periodontal disease, corneal ulceration, are described. For example, N-(2-thiomethyl-4-phenyl-butanoyl)-L-leucinamide was prepared and its inhibitory activity against stromelysin was tested in vitro. |
