Controlled-ph formulation for intravesicular instillation of tgfalphape-40ab

摘要

A buffered intravesicular pharmaceutical dosage system for delivery of TGF alpha PE40ab to a human bladder for bladder cancer chemotherapy, in which a buffer system of 100 mM phosphate at an initial pH of 7.8 maintains a pH range in the bladder of 6.5 to 7.8 that is sufficient to maximize interaction of TGF alpha PE40ab with the EGF receptor expressed on the surface of bladder cancer cells and to prevent aggregation of the TGF alpha PE40ab while in the bladder.