| 摘要 |
PCT No. PCT/US93/06446 Sec. 371 Date Mar. 24, 1995 Sec. 102(e) Date Mar. 24, 1995 PCT Filed Jul. 12, 1993 PCT Pub. No. WO94/07867 PCT Pub. Date Apr. 14, 1994This invention relates to methods of inhibiting sorbitol dehydrogenase, lowering fructose levels, and treating or preventing diabetic complications such as diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic microangiopathy or diabetic macroangiopathy in a mammal using pyrimidine derivatives of formula (I) wherein R1, R2, R3, R4 and R5 are defined as below, and to pharmaceutical compositions containing such derivatives. It also relates to certain novel substituted pyrimidines having the above formula. It also relates to mutual prodrugs of compounds of above formula (I) and aldose reductase inhibiting compounds, and to pharmaceutical compositions comprising a compound of above formula (I) and an aldose reductase inhibitor. |
