2,6-disubstituted purine derivatives

摘要

This application relates to methods of treating myocardial or cerebral ischemia, comprising administering a compound of formula I: (I) wherein X is halogen, perhalomethyl, cyano, C1-6-alkoxy, C1-6-alkylthio or C1-6-alkylamino; and R1 is selected from N-bonded heterocycles. The compound with the greatest ability to discriminate between the A1 and A2 adenosine receptors is 2-chloro-N-[4-phenoxy-1-piperidinyl]adenosine.