发明名称 |
Pulmonary surfactant protein and related polypeptide. |
摘要 |
<p>Polypeptides consisting essentially of from about 10 to about 60 amino acid residues having alternating hydrophobic and hydrophilic amino acid residue regions are useful as pulmonary surfactants when admixed with a pharmaceutically acceptable phospholipid. The polypeptides may be represented by the formula (ZaUb)cZd, wherein: Z is a hydrophilic amino acid residue independently selected from R, D, E and K; U is a hydrophobic amino acid residue independently selected from V, I, L, C, Y and F; a has an average value of about 1 to about 5; b has an average value of about 3 to about 20; c is 1 to 10; and d is 0 to 3.y of</p> |
申请公布号 |
EP0593094(A2) |
申请公布日期 |
1994.04.20 |
申请号 |
EP19930119102 |
申请日期 |
1989.01.05 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
COCHRANE, CHARLES G.;REVAK, SUSAN D. |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61P11/00;C07K7/06;C07K7/08;C07K14/00;C07K14/435;C07K14/785;C12N5/10;C12P21/02;C12R1/91;(IPC1-7):C07K7/06;A61K37/02;C07K7/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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