Cephalosporin compounds and antibacterial agents.

摘要

This invention provides new cephalosporin compounds represented by the following general formula: [wherein R<1> and R<2> are same or different hydrogen atom or a lower alkyl group of 1 to 5 carbon atoms; R<3> is a lower alkyl group which may optionally be substituted with a halogen atom (or atoms), an alkenyl group, or a cycloalkylmethyl group of 3 to 6 carbon atoms; and A is hydrogen atom or residue of a nucleophilic compound] and pharmacologically acceptable salts thereof. These novel compounds have broad-spectrum antibacterial activity against Gram-positive and -negative bacteria including Pseudomonas aeruginosa, as well as against a great variety of beta -lactamase-producing strains.