发明名称 |
A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
摘要 |
The instant invention provides novel molecules derived from the components of proinsulin using recombinant DNA technology. The invention provides molecules of the formula A-C-B wherein A is the A-chain of an insulin species, B is the B-chain of an insulin species and C is a connecting peptide. These molecules possess insulin-like activity and are useful for the treatment of diabetes mellitus, particularly non-insulin dependent diabetes mellitus. These molecules are also useful for the production of insulin and constitute a novel pathway for the recombinant production of insulin species. The invention provides a method of making insulin proceeding through the compounds of the invention as intermediates. The instant invention further provides recombinant DNA compounds which encode the compounds of the invention.
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申请公布号 |
US5304473(A) |
申请公布日期 |
1994.04.19 |
申请号 |
US19910715183 |
申请日期 |
1991.06.11 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BELAGAJE, RAMA M.;DIMARCHI, RICHARD D.;HEATH, JR., WILLIAM F.;LONG, HARLAN B. |
分类号 |
A61K38/28;A61K38/00;A61P3/08;A61P3/10;C07K14/575;C07K14/62;C07K19/00;C12N1/21;C12N15/09;C12N15/17;C12P21/02;C12P21/06;C12R1/19;(IPC1-7):C12P19/34;C12N1/20;A61K37/02;C07K5/00 |
主分类号 |
A61K38/28 |
代理机构 |
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