| 发明名称 |
Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors |
| 摘要 |
The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
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| 申请公布号 |
US5304482(A) |
申请公布日期 |
1994.04.19 |
| 申请号 |
US19900589554 |
申请日期 |
1990.09.28 |
| 申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SAMBROOK, JOSEPH F.;MADISON, EDWIN L.;GOLDSMITH, ELIZABETH J.;GETHING, MARYJANE H. |
| 分类号 |
A61K38/46;A61K31/00;A61K38/00;A61K38/48;A61P7/00;A61P7/02;A61P9/10;C07H21/04;C07K14/005;C07K14/195;C07K14/47;C07K14/81;C12N1/21;C12N9/04;C12N9/50;C12N9/64;C12N9/72;C12N9/76;C12N9/99;C12N15/09;C12N15/10;C12N15/57;C12N15/58;C12N15/71;C12N15/85;C12R1/19;C12R1/91;(IPC1-7):C12N9/64;C12N15/00 |
主分类号 |
A61K38/46 |
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