| 摘要 |
PURPOSE: To obtain immune globulin-G-pharmaceuticals which allow rapid and easy intravenous administration with high purity without adverse effects by processing an immune globulin-G-contg. compd. from which coagulation factors are removed, then separating the compd. by refining. CONSTITUTION: The immune globulin-G-contg. compd. obtd. by chromatography which is subjected to a sterilization treatment or from a cone stage is treated by 0.4 to 1.5 vol. octanic acid, by which protease and vasoactive material are removed. The soln. is then refined and/or the resulted soln. is separated in the phase suitable for high performance liquid chromatography by using cation and anion exchangers, by which the intravenous compatible and non-denatured pharmaceuticals are obtd. The immune globulin pharmaceuticals exhibiting the high antibody titre to viruses, the bacteria, cellular antigens, etc., and are useful for the treatment of the immunodefficiency diseases. |
