Zyklische Ether-Derivate, Verfahren zu deren Herstellung und deren Anwendung.

摘要

Compounds of formula (I): [wherein: l is 2 - 4; A and B are oxygen or sulphur; one of R<1> and R<2> represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R<1> and R<2> represents a group of formula (III): in which E represents a single bond, a bivalent heterocyclic group or a group of formula -CO-, -COO- or -CONR<6>-, where R<6> is hydrogen or an imino-protecting group; m is 0 - 3; n is 0 - l0; q is 0 or l; R<4> is optionally protected hydroxy, mercapto or carboxy; and Q is an amino or nitrogen-containing heterocyclic group] are PAF antagonists which may be used to treat asthma, hypotension, inflammation and shock. They may be prepared by introducing the appropriate group R<1> and/or R<2> into a compound in which one or both of these groups is replaced by an active group.