TWO-PHASE MATRIX FOR SUSTAINED RELEASE DRUG DELIVERY DEVICE

摘要

A two-phase hydrophilic drug-containing matrix for use in transdermal drug delivery patches (10) in which one phase is a continuous hydrophobic polymer phase which optionally includes a hydrophobic solvent that acts as a skin permeation enhancer and the other phase is a dispersed particulate hydrated inorganic silicate in whose absorbed aqueous phase the drug is dissolved. A simple transdermal patch structure (10) contains a backing layer (11), a matrix layer (12) and a release liner layer (13) as components.